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23 May 2002 Influence of tissue movements on laser Doppler perfusion imaging
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The microvascular perfusion can be measured using laser Doppler blood flowmetry (LDF), a technique sensitive to the concentration of moving blood cells and their velocity. However, movements of the tissue itself can cause artifacts in the perfusion readings. In a clinical situation, these movement induced artifacts may arise from patient movements or from movements of internal organs e.g. the intestines or the beating heart. Therefore, we have studied how a well-controlled tissue movement affects the LDF signals during different flow conditions and for different surface structures. Tissue perfusion was recorded non-touch in one point using a laser Doppler perfusion imager. During the measurements the object was placed on a shaker that generated the movement (both horizontal and vertical). Measurements were carried out both on DELRIN (polyacetal plastic) and the fingertip, for a wide range of velocities (0-3 cm/s). The influence of the microvascular perfusion was evaluated by occluding the brachial artery as well as blood emptying the finger and by using a flow model. The LDF signals were correlated to the movement. In vivo measurements showed that velocities above 0.8 cm/s gave a significant contribution to the perfusion signal. Corresponding velocities for the DELRIN piece were higher (1.4 - 2.6 cm/s), and dependent on the surface structures and reflecting properties. By reducing the amount of specular reflection the movement influence was substantially lowered.
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Daniel M.G. Karlsson, Marcus Larsson, Tomas Stroemberg, and Karin Wardell "Influence of tissue movements on laser Doppler perfusion imaging", Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002);

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