23 May 2002 Monte Carlo simulation of NIR spectrum changes induced by variations of glucose concentration
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We have analyzed the light propagation in tissue simulating media by a Monte Carlo method, using the estimated changes in the optical properties caused by variation of glucose concentration and temperature of the media. Using the calculated data, we have predicted the changes in the absorbance spectra caused by the change in glucose concentration in the absorbing and scattering medium. The predicted spectra have agreed very well with those obtained by the experiments. We have also studied the effects of the varying scattering coefficient on the spectra, and found that the changes in the absolute value and the wavelength dependency of the scattering coefficient are closely related to the changes in the observed spectra. In addition, we have calculated the changes in the absorbance spectra, when the glucose concentration and the temperature of glucose solution vary simultaneously. Using the multivariate analysis, we have extracted the glucose concentration accurately from the calculated absorbance spectra.
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Masatoshi Tarumi, Masatoshi Tarumi, Mitsunori Shimada, Mitsunori Shimada, Tomoya Murakami, Tomoya Murakami, Mamoru Tamura, Mamoru Tamura, Miho Shimada, Miho Shimada, Yukio Yamada, Yukio Yamada, } "Monte Carlo simulation of NIR spectrum changes induced by variations of glucose concentration", Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002); doi: 10.1117/12.468324; https://doi.org/10.1117/12.468324

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