23 May 2002 Online measurement of urea concentration in spent dialysate during hemodialysis
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Proceedings Volume 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II; (2002); doi: 10.1117/12.468312
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States
Abstract
We describe on-line optical measurements of urea concentration during the regular hemodialysis treatment of several patients. The spectral measurements were performed in the effluent dialysate stream after the dialysis membrane using an FTIR spectrometer equipped with a flow-through cell. Spectra were recorded across the 5000-4000 cm-1 (2.0-2.5 micrometers at 1-minute intervals. Optically determined concentrations matched concentrations obtained from standard chemical assays with a root-mean-square error of 0.29 mM for urea (0.8 mg/dl urea nitrogen), 0.03 mM for creatinine, 0.11 mM for lactate, and 0.22 mM for glucose. The observed concentration ranges were 0-11 mM for urea, 0-0.35 mM for creatinine, 0-0.75 mM for lactate, and 9-12.5 mM for glucose.
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Jonathon T. Olesberg, Ben Armitage, Mark A. Arnold, Michael Flanigan, "Online measurement of urea concentration in spent dialysate during hemodialysis", Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002); doi: 10.1117/12.468312; https://doi.org/10.1117/12.468312
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KEYWORDS
Urea

Calibration

Glucose

Urea concentration

Absorbance

Optical filters

Process modeling

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