Nanoparticle-based optical detection of molecular interactions of DNA-chip technology

Wolfgang Fritzsche; Andrea Csaki; Robert Moeller

doi:10.1117/12.472097

21 June 2002 Nanoparticle-based optical detection of molecular interactions of DNA-chip technology

Wolfgang Fritzsche, Andrea Csaki, Robert Moeller

Proceedings Volume 4626, Biomedical Nanotechnology Architectures and Applications; (2002) https://doi.org/10.1117/12.472097
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

We adapted the nanoparticle-labeling technique from microscopical applications for DNA-chip detection. Nanoparticles can be detected by simple optical means, and exhibit a high stability. So alternative optical readout devices can be applied for the detection of specific DNA- binding on microstructured spots of complementary, surface- immobilized capture DNA. Several devices were tested, and the binding of gold-labeled DNA to complementary and non- complementary sequences was investigated using optical detection of the gold-labeled substrates before and after silver enhancement.

Citation Download Citation

Wolfgang Fritzsche, Andrea Csaki, and Robert Moeller "Nanoparticle-based optical detection of molecular interactions of DNA-chip technology", Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); https://doi.org/10.1117/12.472097

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