MR diagnostics with obtaining images cleaned of strong signals of water and fat for discovery small tissue contrast variations related with a pathology is discussed. With help of water suppression, one can reveal the pathological changes of brain in small zones near the liquor spaces, particularly disseminated sclerosis cortical plaques, cerebral lesions, subarachnoid hemorrhage. Under the fat suppression T2-weighted images, inflammatory changes in orbits, cranial base, and spine are surely determined. Among several methods of water or fat suppression, one can indicate methods based on frequency selective saturation of fat signals and methods based on inversion-recovery (IR) pulse sequence. Simultaneous suppression of fat and water opens up additional possibilities in medical diagnostics. We realized simultaneous suppression of fat and water signals at the MR scanner Tomikon S50 (Bruker). We used a pulse sequence based on the IR technique, supplemented with special procedure of frequency-selective fat saturation. Sometimes only simultaneous suppression of fat and water signal made possible successful MRI diagnostics.