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9 May 2002 Automated quantification of MS lesions in MRI: a validation study
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Two novel methods for automated quantification of total lesion burden in multiple sclerosis patients using multi-spectral magnetic resonance (MR) imaging are examined. The first method, geometrically constrained region growth, requires user specification of lesion location. The second, directed multi-spectral segmentation, requires only the location of a single exemplar lesion. The performances of these methods are compared to manual tracing using three parameters: speed, precision, and accuracy. Both methods are shown to provide significant improvement over manual tracing in terms of processing time, inter- and intra-operator coefficients of variation, and global accuracy using both phantoms and clinical data.
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Edward A. Ashton, Chihiro Takahashi, Michel J. Berg, Andrew Goodman, and Saara Totterman "Automated quantification of MS lesions in MRI: a validation study", Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002);

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