9 May 2002 Robustness of the brain parenchymal fraction for measuring brain atrophy
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Other researchers have proposed that the brain parenchymal fraction (or brain atrophy) may be a good surrogate measure for disease progression in patients with Multiple Sclerosis. This paper considers various factors influencing the measure of the brain parenchymal fraction obtained from dual spin-echo PD and T2-weighted head MRI scans. We investigate the robustness of the brain parenchymal fraction with respect to two factors: brain-mask border placement which determines the brain intra-dural volume, and brain scan incompleteness. We show that an automatic method for brain segmentation produces an atrophy measure which is fairly sensitive to the brain-mask placement. We also show that a robust, reproducible brain atrophy measure can be obtained from incomplete brain scans, using data in a centrally placed subvolume of the brain.
© (2002) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
M. Stella Atkins, M. Stella Atkins, Jeffery J. Orchard, Jeffery J. Orchard, Benjamin Law, Benjamin Law, Melanie K. Tory, Melanie K. Tory, } "Robustness of the brain parenchymal fraction for measuring brain atrophy", Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); doi: 10.1117/12.467153; https://doi.org/10.1117/12.467153

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