Detection and three-dimensional visualization of lesion models using sonoelastography

Lawrence S. Taylor; Thomas Roger Gaborski; John G. Strang; Deborah Rubens; Kevin J. Parker

doi:10.1117/12.462182

11 April 2002 Detection and three-dimensional visualization of lesion models using sonoelastography

Lawrence S. Taylor, Thomas Roger Gaborski, John G. Strang, Deborah Rubens, Kevin J. Parker

Proceedings Volume 4687, Medical Imaging 2002: Ultrasonic Imaging and Signal Processing; (2002) https://doi.org/10.1117/12.462182
Event: Medical Imaging 2002, 2002, San Diego, California, United States

Abstract

Sonoelastography is a vibration Doppler technique for imaging the relative elasticity of tissues. Detectability of hard lesions of various sizes has previously been demonstrated in tissue phantoms by our group. Because real tissue differs from phantom material, the injection of formaldehyde in fresh liver tissue is being used as an in-vitro lesion model. Pieces of fresh calf liver were embedded in an agar gel then injected with a bolus of 37% formaldehyde to create a stiff lesion. Two and three-dimensional sonoelastography and b-mode images were acquired. The lesions were visible in each sonoelastography image as a region of reduced vibration. After imaging, lesions were dissected and measured for size and volume. One 0.4 cc bolus injection of formaldehyde created a lesion with a volume of 10.3 cc in the sonoelastography image compared to 9.3 cc using fluid displacement of the dissected lesion. A 0.33 cc injection of formaldehyde lesion created a volume of 5 cc in the sonoelastography image compared to 4.4 cc using fluid displacement. Sonoelastography imaging techniques for imaging hard lesions in phantoms can be successfully extended to imaging formaldehyde induced lesions in real tissue.

Citation Download Citation

Lawrence S. Taylor, Thomas Roger Gaborski, John G. Strang, Deborah Rubens, and Kevin J. Parker "Detection and three-dimensional visualization of lesion models using sonoelastography", Proc. SPIE 4687, Medical Imaging 2002: Ultrasonic Imaging and Signal Processing, (11 April 2002); https://doi.org/10.1117/12.462182

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