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16 July 2002 Functional cerebral activation detected by frequency-domain near-infrared spectroscopy
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The aim of our study was to explore the possibility of detecting haemodynamic changes in the brain using frequency- domain near-IR spectroscopy by exploiting the phase of the intensity modulated optical signal. To obtain optical signals with eh highest possible signal-to-noise ratio, we performed simultaneous NIRS-fMRI measurements, with subsequent correlation of the time courses of both measurements. The cognitive paradigm used arithmetic calculations, with optical signals acquired with sensors placed on the forehead. In three subjects we demonstrated correlation between the haemodynamic signals obtained using NIRS and BOLD fMRI.
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Vladislav Yu. Toronov, Andrew G. Webb, Jee Hyun Choi, Martin Wolf, Larisa P. Safonova, Ursula Wolf, and Enrico Gratton "Functional cerebral activation detected by frequency-domain near-infrared spectroscopy", Proc. SPIE 4707, Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III, (16 July 2002);

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