Mathematical model of cAMP-dependent signaling pathway in constitutive and UV-induced melanogenesis

Mikhail M. Stolnitz; Anna Yu. Peshkova

doi:10.1117/12.475600

16 July 2002 Mathematical model of cAMP-dependent signaling pathway in constitutive and UV-induced melanogenesis

Mikhail M. Stolnitz, Anna Yu. Peshkova

Proceedings Volume 4707, Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III; (2002) https://doi.org/10.1117/12.475600
Event: Saratov Fall Meeting 2001, 2001, Saratov, Russian Federation

Abstract

Cascade of reactions of cAMP-dependent signaling pathway in melanocytes is investigated by mathematical modeling. Model takes into account (alpha) -melanocyte stimulating hormone binding to melanocortin-1 receptor, adenylate cyclase activation by G-protein, increase of the intracellular cAMP concentration, PKA activation by cAMP, CREB phosphorylation by PKA, microphthalmia gene expression, microphthalmia binding to tyrosinase gene promoter, increase of tyrosinase synthesis. Positive and negative feedback loops of this system are analyzed.

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Mikhail M. Stolnitz and Anna Yu. Peshkova "Mathematical model of cAMP-dependent signaling pathway in constitutive and UV-induced melanogenesis", Proc. SPIE 4707, Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III, (16 July 2002); https://doi.org/10.1117/12.475600

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