16 July 2002 Mathematical model of cAMP-dependent signaling pathway in constitutive and UV-induced melanogenesis
Author Affiliations +
Abstract
Cascade of reactions of cAMP-dependent signaling pathway in melanocytes is investigated by mathematical modeling. Model takes into account (alpha) -melanocyte stimulating hormone binding to melanocortin-1 receptor, adenylate cyclase activation by G-protein, increase of the intracellular cAMP concentration, PKA activation by cAMP, CREB phosphorylation by PKA, microphthalmia gene expression, microphthalmia binding to tyrosinase gene promoter, increase of tyrosinase synthesis. Positive and negative feedback loops of this system are analyzed.
© (2002) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Mikhail M. Stolnitz, Mikhail M. Stolnitz, Anna Yu. Peshkova, Anna Yu. Peshkova, } "Mathematical model of cAMP-dependent signaling pathway in constitutive and UV-induced melanogenesis", Proc. SPIE 4707, Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III, (16 July 2002); doi: 10.1117/12.475600; https://doi.org/10.1117/12.475600
PROCEEDINGS
9 PAGES


SHARE
Back to Top