30 May 2002 Neoplasm diagnostics based on fluorescence of polymethine dyes
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Investigated polymethine dye TICS has near IR bands of fluorescence and absorption within the transparency region of biological tissues. It can be detected up to 1.5 cm from the surface of the skin. The intensity of a fluorescence signal of TICS is linear for doses up to 2 mg/kg in both tumor and muscle tissue. The ratio of an intensity of light induced fluorescence in tumor tissue to one in muscle tissue is up to 3.6 for rapidly growing tumors. The retention time of TICS is 7 days in all tissues. TICS can be used in the detection of tumor boundaries and tumor internal structure.
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Michael Petrovitch Samtsov, Michael Petrovitch Samtsov, Eugene S. Voropay, Eugene S. Voropay, Vadim N. Chalov, Vadim N. Chalov, Edvard A. Zhavrid, Edvard A. Zhavrid, } "Neoplasm diagnostics based on fluorescence of polymethine dyes", Proc. SPIE 4749, ICONO 2001: Novel Trends in Nonlinear Laser Spectroscopy and Optical Diagnostics and Lasers in Chemistry, Biophysics, and Biomedicine, (30 May 2002); doi: 10.1117/12.468904; https://doi.org/10.1117/12.468904

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