Evaluation of x-ray detectors for dual-modality CT-SPECT animal imaging

Lawrence R. MacDonald; Koji Iwata; Bradley E. Patt; Jan S. Iwanczyk; Andrew B. Hwang; Max C. Wu; Bruce H. Hasegawa

doi:10.1117/12.456316

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26 November 2002 Evaluation of x-ray detectors for dual-modality CT-SPECT animal imaging

Lawrence R. MacDonald, Koji Iwata, Bradley E. Patt, Jan S. Iwanczyk, Andrew B. Hwang, Max C. Wu, Bruce H. Hasegawa

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Proceedings Volume 4786, Penetrating Radiation Systems and Applications IV; (2002) https://doi.org/10.1117/12.456316
Event: International Symposium on Optical Science and Technology, 2002, Seattle, WA, United States

Abstract

We are developing a bench-top animal scanner that will acquire both functional SPECT images and anatomical CT images with sub-millimeter spatial resolution for both imaging modalities. This paper presents preliminary results from the evaluation of two x-ray detectors for the CT application, and dual SPECT-CT images using one of these detectors. Two phosphor-CMOS x-ray detectors, one with 48 m pixels and 5 cm x 5 cm area and the other with 50 μm pixels and 12 cm x 12 cm area, were evaluated for linearity and dynamic range. Each detector showed linearity over ~ 3 orders of magnitude, which is sufficient for mouse CT imaging. The smaller detector was mounted to an A-SPECT system, along with a custom 50 W x-ray source with focal spot size of ~ 150 μm. Phantoms and mice were scanned sequentially, SPECT followed by CT, and the resulting reconstructed images fused into a single SPECT-CT image. These preliminary results show that the two detectors evaluated for this application can successfully achieve high contrast CT images of mice and similar sized objects.

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Lawrence R. MacDonald, Koji Iwata, Bradley E. Patt, Jan S. Iwanczyk, Andrew B. Hwang, Max C. Wu, and Bruce H. Hasegawa "Evaluation of x-ray detectors for dual-modality CT-SPECT animal imaging", Proc. SPIE 4786, Penetrating Radiation Systems and Applications IV, (26 November 2002); https://doi.org/10.1117/12.456316

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