Evaluation of x-ray detectors for dual-modality CT-SPECT animal imaging

Lawrence R. MacDonald; Koji Iwata; Bradley E. Patt; Jan S. Iwanczyk; Andrew B. Hwang; Max C. Wu; Bruce H. Hasegawa

doi:10.1117/12.456316

26 November 2002 Evaluation of x-ray detectors for dual-modality CT-SPECT animal imaging

Lawrence R. MacDonald; Koji Iwata; Bradley E. Patt; Jan S. Iwanczyk; Andrew B. Hwang; Max C. Wu; Bruce H. Hasegawa

Author Affiliations +

Proceedings Volume 4786, Penetrating Radiation Systems and Applications IV; (2002) https://doi.org/10.1117/12.456316
Event: International Symposium on Optical Science and Technology, 2002, Seattle, WA, United States

Abstract

We are developing a bench-top animal scanner that will acquire both functional SPECT images and anatomical CT images with sub-millimeter spatial resolution for both imaging modalities. This paper presents preliminary results from the evaluation of two x-ray detectors for the CT application, and dual SPECT-CT images using one of these detectors. Two phosphor-CMOS x-ray detectors, one with 48 m pixels and 5 cm x 5 cm area and the other with 50 μm pixels and 12 cm x 12 cm area, were evaluated for linearity and dynamic range. Each detector showed linearity over ~ 3 orders of magnitude, which is sufficient for mouse CT imaging. The smaller detector was mounted to an A-SPECT system, along with a custom 50 W x-ray source with focal spot size of ~ 150 μm. Phantoms and mice were scanned sequentially, SPECT followed by CT, and the resulting reconstructed images fused into a single SPECT-CT image. These preliminary results show that the two detectors evaluated for this application can successfully achieve high contrast CT images of mice and similar sized objects.

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Lawrence R. MacDonald, Lawrence R. MacDonald, Koji Iwata, Koji Iwata, Bradley E. Patt, Bradley E. Patt, Jan S. Iwanczyk, Jan S. Iwanczyk, Andrew B. Hwang, Andrew B. Hwang, Max C. Wu, Max C. Wu, Bruce H. Hasegawa, Bruce H. Hasegawa, } "Evaluation of x-ray detectors for dual-modality CT-SPECT animal imaging", Proc. SPIE 4786, Penetrating Radiation Systems and Applications IV, (26 November 2002); doi: 10.1117/12.456316; https://doi.org/10.1117/12.456316

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