4 October 2002 Synthesis and surface modification of superparamagnetic nanoparticles for biomedical applications
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Abstract
Monodispersed superparamagnetic nanoparticles were synthesized from aqueous iron chloride solutions and were modified with poly(ethylene glycol) self assembled monolayers to improve their dispersion, biocompatibility and intracellular uptake for biomedical applications. Transmission electron micrographs (TEM) and atomic force microscopy (AFM) showed an average particle size of 10-30 nm and confirmed particle dispersion following surface modification with PEG. Fourier transform infrared spectroscopy (FTIR) confirmed the presence of PEG on the nanoparticle surface and the particles were further characterized with electron energy loss spectroscopy (EELS).
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Nathan Kohler, Nathan Kohler, Yong Zhang, Yong Zhang, Brad Busche, Brad Busche, Miqin Zhang, Miqin Zhang, } "Synthesis and surface modification of superparamagnetic nanoparticles for biomedical applications", Proc. SPIE 4810, Properties of Metal Nanostructures, (4 October 2002); doi: 10.1117/12.453767; https://doi.org/10.1117/12.453767
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