The Sloan Digital Sky Survey represents a new paradigm for optical astronomy. It is a consortium involving several hundred astronomers from the US, Japan, and Germany, and aims to obtain basic photometric and spectroscopic data of a large representative region of the high Galactic latitude sky. Using a dedicated wide-field 2.5m telescope and unique instrumentation and software, it is imaging the sky in five photometric bands, and obtaining high-quality spectra of magnitude-limited samples of galaxies and quasars. Many of the exciting scientific results to come from this survey have been a result of follow-up of the intriguing objects found with SDSS on larger and specialized instruments, including Keck, the VLT, and the Hobby-Eberly Telescope. I discuss the synergy between the SDSS and the larger telescopes, with emphasis on studies of high-redshift quasars, and discuss how the SDSS and similar surveys are performing an important role in providing the basis for studies with these larger telescopes.