Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies

Guoqiang Yu; Turgut Durduran; Daisuke Furuya; Joel H. Greenberg; Arjun G. Yodh

doi:10.1117/12.482951

12 September 2002 Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies

Guoqiang Yu, Turgut Durduran, Daisuke Furuya, Joel H. Greenberg, Arjun G. Yodh

Author Affiliations +

Proceedings Volume 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment; (2002) https://doi.org/10.1117/12.482951
Event: Photonics Asia, 2002, Shanghai, China

Abstract

Measurement of concentration, oxygenation, and flow characteristics of blood cells can reveal information about tissue metabolism and functional heterogeneity. An instrument has been built that combines two near-infrared diffuse optical techniques to simultaneously monitor blood flow, blood volume and blood oxygen saturation. Diffuse correlation spectroscopy (DCS) monitors blood flow by measuring the optical phase shifts caused by moving blood cells, while diffuse photon density wave (DPDW) spectroscopy measured tissue absorption and scattering. The modularized design of the instrument provides the instrument great flexibility for trading off the temporal, spectral and spatial resolution by selecting the number of source-detector pairs and wavelengths. The frame acquisition rate of the current instrument is 0.2 Hz with 3? (wavelengths) × 15s (source positions) × 4d (detectors) for DPDW measurement in the frequency domain, and 1? × 3s × 9d for DCS. Higher frame acquisition rate could be achieved by reducing the spatial resolution, for example, 2 Hz with 3? × 1s × 4d for DPDW and 1? × 1s × 9d for DCS. The unique non-contact probe mounted on the back of a camera allows non-contact measurement that avoids potentially altering blood flow. We used this instrument to monitor in vivo the hemodynamic responses in rat brain during KCl induced cortical spreading depression (CSD).

Citation Download Citation

Guoqiang Yu, Turgut Durduran, Daisuke Furuya, Joel H. Greenberg, and Arjun G. Yodh "Hemodynamic measurements in rat brain combining diffuse near-infrared absorption and correlation spectroscopies", Proc. SPIE 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment, (12 September 2002); https://doi.org/10.1117/12.482951

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Sensors

Spectroscopes

Blood

Blood circulation

Tissue optics

Absorption

Show All Keywords

Keywords/Phrases

Search In:

Publication Years