12 September 2002 Low-cost multibeam optical tweezers with Laguerre-Gaussian mode and its manipulation of cells
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Abstract
Optical tweezers are useful tools for use as non-contact micromanipulators of biological cells and organisms. Conventionally, a Gaussian laser mode is used as the trapping beam. In this paper, the authors describe a detailed recipe for construction of a low cost dual optical tweezers. The system is based on a conventional optical microscope and high-order Laguerre-Gaussian beam lasers. The authors studied both Laguerre-Gaussian beam trap and Gaussian beam trap's characteristics. It has been found that the high-order Laguerre-Gaussian beam trap has many significant advantages: the high-order Laguerre-Gaussian beam trap can hold larger particles more stable than Gaussian beam trap; a single Laguerre-Gaussian beam trap is able to catch free cells and hold them together simultaneously, but traditionally only the multi-Gaussian beam optical traps can fulfill the work; the high-order Laguerre-Gaussian beam trap is safer than the Gaussian beam trap. In addition, the high-order mode laser is inexpensive and the low cost system will make this technique more widely accessible to researchers.
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Xiuzhou Feng, Xiuzhou Feng, Tianchun Zhu, Tianchun Zhu, } "Low-cost multibeam optical tweezers with Laguerre-Gaussian mode and its manipulation of cells", Proc. SPIE 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment, (12 September 2002); doi: 10.1117/12.482992; https://doi.org/10.1117/12.482992
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