12 September 2002 Multiple diagnosis based on photoplethysmography: hematocrit, SpO2, pulse, and respiration
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Photo-plethysmography measure pulsatile blood flow in real-time and non-invasively.One of widely known application of PPG is a measurement of saturated oxygen in arterial blood (SpO2). In our work , using several wave length more than those used in a pulse oximeter, an algorithm and instrument have been developed to measure hematocrit, saturated oxygen pulse and respiratory rates simultaneously.To predict hemotocrit, a dedicated algorithm is developed based on scattering of RBC and a protocall for detecting outlier signal is used to increase accuracy and reliability.Digital filtering techniques are used to exart respiratory rate signal. Utilization of wave length under 1000nm and a multi-wavelength LED array chip and digital-oriented electronic enable us to make a compact device. Our preliminary clinical trails shown that the achived percent errors are±8.2% for hematocrit when tested with 594 person ,r2 for SpO fitting is 0.99985 when tested with a Bi-Tek pulse oximeter simulator and the SPO2 error for in vivo test is ±2.5% over the range of 75~100%. The error of pulse rates is less than ±5%. We obtained a positive predictive value of 96% for respiratory rates in qualitative analysis.
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Gilwon Yoon, Gilwon Yoon, Jong Youn Lee, Jong Youn Lee, Kye Jin Jeon, Kye Jin Jeon, Kun-Kook Park, Kun-Kook Park, Hyung S. Yeo, Hyung S. Yeo, Hyun Tae Hwang, Hyun Tae Hwang, Hong Sig Kim, Hong Sig Kim, In-Duk Hwang, In-Duk Hwang, "Multiple diagnosis based on photoplethysmography: hematocrit, SpO2, pulse, and respiration", Proc. SPIE 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment, (12 September 2002); doi: 10.1117/12.482947; https://doi.org/10.1117/12.482947

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