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12 September 2002 Noninvasive intracranial pressure measurement using near-infrared light
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Increases in intracranial pressure (ICP) may occur in patients of cerebral edema, brain tumors, encephalitis, brain injury etc. The care of these patients has been improved with continuous ICP monitoring. However, all the present clinical ICP monitors are invasive. Non-invasive ICP monitor is greatly expected. In this paper, a new method for ICP non-invasive monitoring using near-infrared light is proposed. Both theoretical and experimental studies have shown that correlation analysis applied to ICP, cerebrospinal fluid (CSF) and near-infrared diffuse reflection light from the brain tissue provides a possibility for non-invasive ICP detection. First, the correlation between the reflected light and the thickness of CSF is studied with Monte-Carlo simulations. It is concluded that the intensity of the reflected light changes significantly with the thickness of CSF, suggesting the feasibility to detect ICP by measuring the diffuse reflection near-infrared light from the brain tissue because the thickness of CSF changes with ICP. Secondly, the correlation of the diffuse reflection light and ICP is studied based on the experimental data acquired with helps of volunteers. It has been proved very promising to determine ICP non-invasively using near-infrared light.
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Ling Lin, Gang Li, Saoxia Xiang, and Jinfa Sun "Noninvasive intracranial pressure measurement using near-infrared light", Proc. SPIE 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment, (12 September 2002);

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