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12 September 2002 Novel optical imaging system for localization of early nasopharyngeal carcinoma
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By using a commercial nasal endoscope and laser-induced drug fluorescence technique, a novel optical imaging system as a localizer for nasopharyngeal carcinoma that coupled the excitation laser into the original white-light transmission system of endoscope was presented. The design approach of the imaging system and ultimate schematic diagram were also illustrated in detail. The design of optical imaging system mainly including the coupled technique with high efficiency between light source and optical fiber, and the directed coupled technique of two coaxial optical beam from different optical fiber without contact, as well as the technique for better clearness and contrast of displayed image of the optical imaging system. As a result, the fluorescence and reflection white light from the target tissue surface are alternately imaged by a nasal endoscope for respectively, which can be switched in real time for clinical examination of diagnosis and localizati on of early nasopharyngeal carcinoma.
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Shusen Xie, Buhong Li, Qing Ye, and Guiping Shen "Novel optical imaging system for localization of early nasopharyngeal carcinoma", Proc. SPIE 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment, (12 September 2002);

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