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14 November 2002 Disposable biochip fabrication for DNA diagnostics
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The need for disposable diagnostic sensors in the health care industry has been a major factor in the development of low-cost microfluidic devices. Polymer materials have been the obvious choice due to their cost effectiveness. However, these materials often do not possess the desired properties for biochip operation, such as their high non-specific binding and poor electroosmotic flow characteristics. Various fabrication techniques have also been developed for polymeric chips over the past few years due to their incompatibility with the traditionally preferred micromachining technologies associated with glass and silicon. This paper presents a method for constructing microfluidic devices in Poly(ethylene terephthalate) (PET) using a direct-write Neodymium Yttrium Aluminium Garnet (Nd:YAG) laser system. Issues involving the operation and fabrication of such disposable devices, with particular emphasis on the development of a bio-chip for DNA diagnostics, are discussed.
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Micah Atkin, Jason P. Hayes, Narelle Brack, Karl Poetter, Robert Cattrall, and Erol C. Harvey "Disposable biochip fabrication for DNA diagnostics", Proc. SPIE 4937, Biomedical Applications of Micro- and Nanoengineering, (14 November 2002);

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