Measurement of mucosal capillary hemoglobin oxygen saturation in the colon by reflectance spectrophotometry

Shai Friedland; David A. Benaron M.D.; Ilian H. Parachikov; Roy Soetikno

doi:10.1117/12.488351

12 September 2003 Measurement of mucosal capillary hemoglobin oxygen saturation in the colon by reflectance spectrophotometry

Shai Friedland, David A. Benaron M.D., Ilian H. Parachikov, Roy Soetikno

Author Affiliations +

Proceedings Volume 4949, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII; (2003) https://doi.org/10.1117/12.488351
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Advances in optical and computer technology have enabled the development of a device that utilizes white-light reflectance spectrophotometry to measure capillary hemoglobin saturation in intestinal mucosa during colonoscopy. Studies were performed using the colon oximeter in anesthetized animals and patients undergoing colonoscopy. Mucosal hemoglobin saturation in the normal colon (mean +/- S.D.) is 72% +/- 3.5%. In an animal model, ischemia via arterial ligation and hypoxemia via hypoxic ventilation each result in a decrease of over 40% in the mucosal saturation. In human patients with colon polyps, ischemia induced by epinephrine injection, stalk ligation using a loop, or clipping of the polyp stalk each result in a decrease of over 40% in the mucosal saturation (p<0.02). In contrast, saline injection does not decrease the mucosal saturation (p=N.S.). A patient who previously underwent partial colectomy with sacrifice of the inferior mesenteric artery had a saturation of 55% in the remaining sigmoid colon, with normal values in the superior mesenteric artery territory (p<0.05). A novel device for measuring capillary hemoglobin saturation in intestinal mucosa during colonoscopy is capable of providing reproducible measurements in normal patients and clearly detects dramatic decreases in saturation with ischemic and hypoxic insults.

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Shai Friedland, David A. Benaron M.D., Ilian H. Parachikov, and Roy Soetikno "Measurement of mucosal capillary hemoglobin oxygen saturation in the colon by reflectance spectrophotometry", Proc. SPIE 4949, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII, (12 September 2003); https://doi.org/10.1117/12.488351

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KEYWORDS

Colon

Oxygen

Spectrophotometry

Ischemia

Reflectivity

Arteries

Capillaries

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