13 June 2003 Development of an in vivo model for the study of photodynamic therapy and anti-angiogenic treatments
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Abstract
An in vivo model has been developed for the study (PDT) and anti-angiogenic treatments. Significant damage to the vasculature of the chick chorioallantoic membrane (CAM) was observed immediately following PDT with 5-aminolevulinic acid (ALA). Multicell human glioma spheriods were placed on the CAM at day five of embryonic development, however, neovascularization was not observed.
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Steen J. Madsen, Chung-Ho Sun, Bruce J. Tromberg, Henry Hirschberg, "Development of an in vivo model for the study of photodynamic therapy and anti-angiogenic treatments", Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); doi: 10.1117/12.474104; https://doi.org/10.1117/12.474104
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