10 June 2003 High-intensity focused ultrasound (HIFU) array system for image-guided ablative therapy (IGAT)
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Recent interest in using High Intensity Focused Ultrasound (HIFU) for surgical applications such as hemostasis and tissue necrosis has stimulated the development of image-guided systems for non-invasive HIFU therapy. Seeking an all-ultrasound therapeutic modality, we have developed a clinical HIFU system comprising an integrated applicator that permits precisely registered HIFU therapy delivery and high quality ultrasound imaging using two separate arrays, a multi-channel signal generator and RF amplifier system, and a software program that provides the clinician with a graphical overlay of the ultrasound image and therapeutic protocol controls. Electronic phasing of a 32 element 2 MHz HIFU annular array allows adjusting the focus within the range of about 4 to 12 cm from the face. A central opening in the HIFU transducer permits mounting a commercial medical imaging scanhead (ATL P7-4) that is held in place within a special housing. This mechanical fixture ensures precise coaxial registration between the HIFU transducer and the image plane of the imaging probe. Recent enhancements include development of an acoustic lens using numerical simulations for use with a 5-element array. Our image-guided therapy system is very flexible and enables exploration of a variety of new HIFU therapy delivery and monitoring approaches in the search for safe, effective, and efficient treatment protocols.
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Peter J. Kaczkowski, Peter J. Kaczkowski, George W. Keilman, George W. Keilman, Bryan W. Cunitz, Bryan W. Cunitz, Roy W. Martin, Roy W. Martin, Shahram Vaezy, Shahram Vaezy, Lawrence A. Crum, Lawrence A. Crum, } "High-intensity focused ultrasound (HIFU) array system for image-guided ablative therapy (IGAT)", Proc. SPIE 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II, (10 June 2003); doi: 10.1117/12.476539; https://doi.org/10.1117/12.476539

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