10 June 2003 MR-guided conformal heating of canine prostate using interstitial applicators
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MRI compatible, multi-element ultrasound applicators were fabricated using cylindrical piezoceramic transducers sectored to 180 degrees to provide angular directional heating. The applicators were designed to be inserted into standard 13 or 14 gage brachytherapy catheters integrated with water-cooling. Two applicators were inserted transperinealy into the posterior region of a canine prostate. Power output ranged from 5-15 W per element during the 15 minute heating period. Phase-sensitive gradient-recalled MR imaging was used to monitor the treatment in real-time on a 0.5 Tesla MRT system. Gadolinium-enhanced T1 weighted images and diffusion-weighted images were obtained to view the regions which had been ablated during the heating procedure. Upon euthanasia, the prostate was removed, axially sectioned, and stained with TTC to reveal any regions of remaining viable tissue. Results from this study indicated a large volume of ablated tissue within the prostate which was highly correlated to the regions in the T1-weighted and diffusion-weighted images which had decreased intensity, and to the 52C contour displayed in the images obtained during the treatment. This study demonstrates the ability to control thermal coagulation within a targeted tissue volume while protecting surrounding tissue from thermal damage.
© (2003) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
William H. Nau, William H. Nau, Chris J. Diederich, Chris J. Diederich, Anthony Ross, Anthony Ross, R. Kim Butts, R. Kim Butts, Viola Rieke, Viola Rieke, Donna Bouley, Donna Bouley, Harchi Gill, Harchi Gill, Bruce Daniel, Bruce Daniel, Graham Sommer, Graham Sommer, } "MR-guided conformal heating of canine prostate using interstitial applicators", Proc. SPIE 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II, (10 June 2003); doi: 10.1117/12.476608; https://doi.org/10.1117/12.476608

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