29 July 2003 Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters
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Abstract
Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO2, tumor vascular oxygenated hemoglobin concentration [HbO2], and tumor oxygen tension pO2) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY) to evaluate dynamic responses of breast tumors to carbogen (5% CO2 and 95% O2) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO2, followed by changes in global tumor vascular [HbO2], and delayed responses for pO2. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.
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Yueqing Gu, Yueqing Gu, Vincent Bourke, Vincent Bourke, Jae Gwan Kim, Jae Gwan Kim, Mengna Xia, Mengna Xia, Anca Constantinescu, Anca Constantinescu, Ralph P. Mason, Ralph P. Mason, Hanli Liu, Hanli Liu, } "Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.479465; https://doi.org/10.1117/12.479465
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