Detection of time window of cerebral blood flow response induced by sciatic nerve stimulation using temporal clustering analysis

Zheng Wang; Qingming Luo; Haiying Cheng; Shaoqun Zeng

doi:10.1117/12.478128

29 July 2003 Detection of time window of cerebral blood flow response induced by sciatic nerve stimulation using temporal clustering analysis

Zheng Wang, Qingming Luo, Haiying Cheng, Shaoqun Zeng

Author Affiliations +

Proceedings Volume 4955, Optical Tomography and Spectroscopy of Tissue V; (2003) https://doi.org/10.1117/12.478128
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

In many studies on functional neuroimaging, change in local cerebral blood flow (CBF) induced by sensory stimulation is used as a substitutive marker for change in cortical neuronal activity by Roy and Sherrington’s postulation. The purpose of this study is to evaluate the close temporal relationship between evoked local CBF and neuronal activity through utilizing temporal clustering analysis (TCA) method to analyze the dataset obtained by high-resolution laser speckle imaging (LSI). We mapped a relatively large somatosensory area of cerebral cortex in successively and followed variations of cerebral blood flow under sciatic nerve stimulation in anesthetized rats using LSI technique. Then we illustrated TCA method on the optical imaging signals and investigated the temporal characteristics of CBF activation. Contralateral somatosensory cortical microflow was activated to increase promptly in less than 1 second after the onset of 2 seconds electrical stimulation (pulse parameters: 0.5ms, 5Hz, 350mV). The data of the present study may possibly shed light on the development question of functional magnetic resonance imaging (fMRI) whether the ultimate spatial resolution attainable by fMRI is limited by the physiology of the cerebral blood flow response to activation or by the hardware and signal-to-noise ratio.

Citation Download Citation

Zheng Wang, Qingming Luo, Haiying Cheng, and Shaoqun Zeng "Detection of time window of cerebral blood flow response induced by sciatic nerve stimulation using temporal clustering analysis", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); https://doi.org/10.1117/12.478128

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Nerve

Cerebral blood flow

Functional magnetic resonance imaging

Neuroimaging

Optical imaging

Signal to noise ratio

Show All Keywords

Keywords/Phrases

Search In:

Publication Years