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29 July 2003 Hybrid DOT and MRI system
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Recently, there has been a great deal of interest in further improving the in-vivo characterization of tumors by interrogating tissues with multiple simultaneous image based measurement techniques that provide complementary information about the functional state of the tissue under investigation. Besides offering the possibility of complementary information, multi-modality techniques could also be used to improve the measurements done by either modality as well as providing cross validation measurements. Magnetic resonance imaging (MRI) and near-infrared diffuse optical tomography (DOT) are two techniques that, when combined, provide complementary structural and functional information. MRI can be used to obtain detailed structural and metabolic information regarding tumors. On the other hand, DOT can be used to determine local quantitative information regarding tumor composition and metabolism. Thus, a combined system consisting of MRI and DOT has the potential to enhance understanding of the complex biological processes in tumors. In this work, we describe the design of the hybrid DOT-MRI system.
© (2003) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Gultekin Gulsen, Ozlem Birgul, and Orhan Nalcioglu "Hybrid DOT and MRI system", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003);

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