29 July 2003 Optical mammography with single-wavelength contrast enhancement and multiwavelength oxygenation assessment
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Abstract
We present a combination of (1) single-wavelength optical mammograms representing either the optical absorbance (N-images) or its spatial second-derivative (N’’-images), and (2) oxygenation-index images based on optical data at four wavelengths (690, 750, 788, and 856 nm). The enhanced contrast of the second-derivative images with respect to the absorbance images is complemented by the functional information provided by the oxygenation-index images. In a number of clinical cases, we have found that breast cancer is often associated with relatively low oxygenation indices, while benign breast lesions correspond to areas with relatively high oxygenation indices. However, the relative nature of the oxygenation-index presented in this work does not allow for a comparison of oxygenation values in different images, for which absolute oxygenation measurements would be needed.
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Sergio Fantini, Sergio Fantini, Erica L. Heffer, Erica L. Heffer, Vivian E. Pera, Vivian E. Pera, Sylvia Heywang-Koebrunner, Sylvia Heywang-Koebrunner, Linda Goetz, Linda Goetz, Anke Heinig, Anke Heinig, Oliver Schuetz, Oliver Schuetz, Horst Siebold, Horst Siebold, } "Optical mammography with single-wavelength contrast enhancement and multiwavelength oxygenation assessment", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478129; https://doi.org/10.1117/12.478129
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