29 July 2003 Random walk analysis of time-resolved transmittance measurements
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Abstract
Many biomedical applications of time-resolved transmittance require precise measurements of optical properties of scattering samples. Recently, random walk theory has been proposed to accurately model the time-resolved transmittance and reflectance across uniform slabs of scattering media as well as slabs containing isolated targets of different scattering or absorbing properties. In this paper random walk description of light propagation in turbid media has been used to analyse transmittance measurements for optical characterization of scattering and absorbing media. A femtosecond Ti:Sa laser working at 800 nm and a streak camera with a time resolution of a few picoseconds have been employed. Various Intralipid suspensions with and without absorbing ink have been investigated. These studies have experimentally confirmed that random walk theory can be usefully employed to discriminate small changes in absorbing and scattering properties. An appropriate fitting procedure, without arbitrary constrains, have been checked and used. In addition, the detailed investigation here reported can help in defining the applicability range of random walk description. This analysis can be important since random walk is a powerful and versatile theory as fast and efficient solution of the inverse problem in optical tomography also for sophisticated geometry and for a wide range of optical properties.
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Ines Delfino, Ines Delfino, Maria Lepore, Maria Lepore, Pietro Luigi Indovina, Pietro Luigi Indovina, } "Random walk analysis of time-resolved transmittance measurements", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.476800; https://doi.org/10.1117/12.476800
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