29 July 2003 Validation of the use of homogeneous reference phantoms for optical tomography of the neonatal brain
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Abstract
Optical tomography is being developed at UCL as a tool for understanding the mechanisms of haemorrhagic and hypoxic-ischaemic brain injury and assessing the effectiveness of novel neural rescue therapies in the newborn infant. Our 32-channel time-resolved optical imaging system measures photon flight times between multiple pairs of points on the surface of the head, and images sensitive to local variation in tissue absorption and scattering properties are reconstructed using non-linear algorithms. Several studies have been performed on premature infants using custom-built helmets, which hold up to 32 sources and detectors in contact with the head. Simulations have revealed that combining data with reference measurements acquired on a homogeneous object using the same fibre locations can significantly reduce errors in reconstructions due to uncertainty in the location of the sources and detectors. To provide the reference data, a homogeneous phantom based on a balloon filled with a scattering fluid of precisely known optical properties was made and inserted into the helmet immediately following each infant scan. In this paper, we evaluate the effectiveness of this approach by acquiring data on a realistically head-shaped phantom containing a small perturbation, and reconstructing it using the homogeneous head-shaped phantom and the fluid-filled balloon.
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Rozarina Md. Yusof, Jeremy C. Hebden, Adam Gibson, Nick Everdell, Topun Austin, Judith H. Meek, Simon Robert Arridge, John S. Wyatt, David T. Delpy, "Validation of the use of homogeneous reference phantoms for optical tomography of the neonatal brain", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478137; https://doi.org/10.1117/12.478137
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