Dynamic study of irradiated artificial skin using OCT

Woonggyu Jung; Bunsho Kao; Kristen M. Kelly; Zhihua Ding; J. Stuart Nelson M.D.; Zhongping Chen

doi:10.1117/12.479043

8 July 2003 Dynamic study of irradiated artificial skin using OCT

Woonggyu Jung, Bunsho Kao, Kristen M. Kelly, Zhihua Ding, J. Stuart Nelson M.D., Zhongping Chen

Proceedings Volume 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII; (2003) https://doi.org/10.1117/12.479043
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

We report a novel application of optical coherence tomography (OCT), to monitor post-laser irradiation collagen injury in skin model. An artificial skin model (RAFT) which closely approximates human skin, was irradiated with a Perovskite laser (λ = 1341 nm). We investigated dynamic changes in a RAFT after laser irradiation through OCT and compared the results to those of histology. OCT images clearly delineated areas of post-irradiation collagen injury and allowed non-invasive monitoring of the wound healing process. Histology was correlated well with OCT images. OCT has advantages because it is non-invasive and allows serial monitoring at the same site over time. Our study showed that OCT may be a useful tool for determination of optimal parameters for non-ablative laser skin rejuvenation (NALSR) using different devices.

Citation Download Citation

Woonggyu Jung, Bunsho Kao, Kristen M. Kelly, Zhihua Ding, J. Stuart Nelson M.D., and Zhongping Chen "Dynamic study of irradiated artificial skin using OCT", Proc. SPIE 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, (8 July 2003); https://doi.org/10.1117/12.479043

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