22 July 2003 Application of high-pressure Raman spectroscopy to bone biomechanics
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Compressive stress on bone, cartilage and other tissues accompanies normal activity. While the biomechanical properties of many tissues are reasonably well-understood at many levels of structure, surprisingly little is known at the ultrastructural and crystal lattice levels. We show how the use of diamond anvil cell Raman microspectroscopy enables a deeper understanding of the response of tissue to mechanical stress. We discuss the reversible responses of deproteinated and intact bone powders to hydrostatic pressure and compare these responses to those of a model compound, synthetic carbonated apatite.
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Michael D. Morris, Michael D. Morris, Olivia de Carmejane, Olivia de Carmejane, Angela Carden, Angela Carden, M. Kathleen Davis, M. Kathleen Davis, Lars Stixrude, Lars Stixrude, Mary Tecklenburg, Mary Tecklenburg, Rupak M. Rajachar, Rupak M. Rajachar, David H. Kohn, David H. Kohn, } "Application of high-pressure Raman spectroscopy to bone biomechanics", Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); doi: 10.1117/12.477940; https://doi.org/10.1117/12.477940

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