22 July 2003 In vivo local determination of tissue optical properties: instrumentation and application
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We have developed an optical probe for local determination of tissue optical properties using a small source-detector separation (<1mm). A 1310nm LED (25 μW) coupled to a fiber with 62.5 μm diameter was used as the light source and multiple detector fibers were employed to achieve spatially resolved reflectance measurement. Each detector fiber has a diameter of 62.5 μm and apart away 125 μm from each other. Pin detectors and continuous wave detection scheme were performed to obtain a sensitivity of 4x109V/W and 82dB dynamic range. Applied to the normal human skin in the forearm, 63dB signal to noise ration can be achieved with a time resolution less than 1 second. The absorption and scattering coefficientions of tissue can be calculated by generalized diffusion approximation with measured reflective intensity. In this paper, we discussed the design of the system in general, and then described our instrument, along with the technique issues that influenced its design. Phantom experimental was performed to analyze the relationship between the reflectance light and the optical properties (μa, μs). The results showed that this optical probe could be used for local determination of tissue optical properties.
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Wei Zhang, Wei Zhang, Hui Gong, Hui Gong, Guiling Wu, Guiling Wu, Pengcheng Li, Pengcheng Li, Qingming Luo, Qingming Luo, } "In vivo local determination of tissue optical properties: instrumentation and application", Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); doi: 10.1117/12.476138; https://doi.org/10.1117/12.476138

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