Utilizing Yucatan mini-pigs for 1318-nm skin exposure ED50 determination

Golda C. H. Winston; Willie L. Greene; Thomas E. Johnson

doi:10.1117/12.477675

27 August 2003 Utilizing Yucatan mini-pigs for 1318-nm skin exposure ED₅₀ determination

Golda C. H. Winston, Willie L. Greene, Thomas E. Johnson

Proceedings Volume 4961, Laser-Tissue Interaction XIV; (2003) https://doi.org/10.1117/12.477675
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Yucatan Mini-pigs were exposed on their flank to 0.5 milli second 1318 nm pulses of laser light. The ED50 damage threshold was determined for this laser exposure combination. The skin was assessed for injury immediately, at 1 hour, 24 hours and three days post exposure. Generally, at least 24 hours was required for visible lesions to form. It was found that as the duration between exposure and assessment expanded the injury was more easily visualized. Tissue samples were collected for histology at one hour, 24 hours and three days. Histologic sections will be presented in future work. It was also found that the topical application of mineral oil to the area of interest was found to greatly increase the ease of identification of injuries.

Citation Download Citation

Golda C. H. Winston, Willie L. Greene, and Thomas E. Johnson "Utilizing Yucatan mini-pigs for 1318-nm skin exposure ED₅₀ determination", Proc. SPIE 4961, Laser-Tissue Interaction XIV, (27 August 2003); https://doi.org/10.1117/12.477675

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