Multimodal miniature microscope (4M Device): novel methodology for multimodality tissue imaging in vivo

Junwon Lee; Jeremy D. Rogers; Dawn L. Nida; Jesse S. Aaron; Konstantin V. Sokolov; Rebecca R. Richards-Kortum; Michael R. Descour

doi:10.1117/12.478121

19 June 2003 Multimodal miniature microscope (4M Device): novel methodology for multimodality tissue imaging in vivo

Junwon Lee, Jeremy D. Rogers, Dawn L. Nida, Jesse S. Aaron, Konstantin V. Sokolov, Rebecca R. Richards-Kortum, Michael R. Descour

Author Affiliations +

Proceedings Volume 4962, Manipulation and Analysis of Biomolecules, Cells, and Tissues; (2003) https://doi.org/10.1117/12.478121
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

We are developing a multi-modal miniature microscope (4M device) for imaging morphology and cytochemistry in vivo and providing better delineation of tumors. The 4M device is designed to be a complete microscope on a chip, including optical, micro-mechanical, and electronic components. It has advantages such as compact size and capability for microscopic-scale imaging. This paper presents the recent imaging experiment of 4M device including trans-illumination imaging, TIR illumination imaging and fluorescent imsging. We built a multi-modal imaging test-bed to demonstrate multi-modality of 4M device. In this paper, we present imaging experiment results by implementing various imaging modality with cervical cancer cells. In order to enhance image contrast, some imaging modality uses cells attached with contrast agency such as silver nano-particles. Imaging results indicate that the 4M prototype can resolve cellular detail necessary for detection of precancer.

Citation Download Citation

Junwon Lee, Jeremy D. Rogers, Dawn L. Nida, Jesse S. Aaron, Konstantin V. Sokolov, Rebecca R. Richards-Kortum, and Michael R. Descour "Multimodal miniature microscope (4M Device): novel methodology for multimodality tissue imaging in vivo", Proc. SPIE 4962, Manipulation and Analysis of Biomolecules, Cells, and Tissues, (19 June 2003); https://doi.org/10.1117/12.478121

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