23 July 2003 Noninvasive in vivo monitoring of total blood hemoglobin
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Blood hemoglobin (Hb) level is an important health parameter for a large segment of the population. Low Hb can indicate anemia due to chemotherapy, HIV, alcoholism, internal bleeding or other blood loss. There is a great need for noninvasive Hb measurement. A total blood Hb measurement method is shown which does not disturb the subject's skin. Results were obtained using MinforMed's noninvasive blood analyzer prototype (patent pending). A light is shined onto a body part, through the skin, engaging the blood. The emerging light is analyzed for Hb's signature strength in the visible and infrared ranges. Orthogonal decomposition methods are used to extract the Hb data from the complete spectrum. Results were compared to a laboratory-grade instrument that uses a drop of blood. A Hb range from 11 g/dL through 19 g/dL shows excellent correlation, r2=0.97. Other characteristics of the complete spectrum give indication of additional blood analytes, most notably bilirubin and water. Initial results are also shown indicating how light scattering varies with Hb concentration. Approximate residual skin and tissue spectrum is found by removing the spectral signature of the four Hb components (oxy-Hb, deoxy-Hb, carboxy-Hb and met-Hb) from the complete spectrum. This procedure yields the least squares concentrations of the individual Hb components. An SBIR grant from NIH is currently in progress on related work.
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Edward Wuori, Edward Wuori, Mary Gmitter, Mary Gmitter, } "Noninvasive in vivo monitoring of total blood hemoglobin", Proc. SPIE 4965, Optical Diagnostics and Sensing in Biomedicine III, (23 July 2003); doi: 10.1117/12.479186; https://doi.org/10.1117/12.479186

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