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23 July 2003 Optical studies of changes in bone mineral density
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The ability to measure changes in bone-mineral-density (BMD) in-vivo has potential applications in monitoring stress-induced bone remodelling in, for example, competition race horses. In this study we have begun to investigate the potential of optical techniques to monitor such changes via changes in bone optical scattering. Using integrating spheres, we have investigated the optical properties of bone samples taken from the leg of the horse. Since our samples have stable characteristics over the time, we are able to use a single integrating-sphere technique. Diffuse reflection and transmission coefficients have been measured over the wavelength range 520 to 960 nm. Measurements were made on samples immersed in formic acid solution for different lengths of time; this was to investigate the effect of reduction in BMD on the optical properties. The experimental results and a Monte-Carlo based inversion method were used to extract the absorption coefficient and unmodified scattering coefficient of the samples. After full demineralisation scattering coefficient fell by a factor 4. This shows that the calcium-content in bone influences its optical properties considerably. Our experiments confirm the possibility of using optical techniques to determine changes in the BMD of samples.
© (2003) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Nadya Ugryumova, Stephen John Matcher, and Don P. Attenburrow "Optical studies of changes in bone mineral density", Proc. SPIE 4965, Optical Diagnostics and Sensing in Biomedicine III, (23 July 2003);

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