18 June 2003 LLNL Center for Microtechnology: capabilities, customers, case study -- HANAA (Handheld Nucleic Acid Analyzer)
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Proceedings Volume 5001, Optical Engineering at the Lawrence Livermore National Laboratory; (2003) https://doi.org/10.1117/12.500360
Event: High-Power Lasers and Applications, 2003, San Jose, CA, United States
Abstract
The polymerase chain reaction (PCR) is an enzyme-based chemical reaction that manufactures copies of one or more identifying regions of double-stranded DNA sequences (target sequences). These copies of target DNA are known as "amplicons". By creating millions of these copies of the identifying sequences (when they are present!), PCR allows researchers to detect by them, and hence the presence of the relevant organism, with techniques such as electrophoresis, flow cytometry, or spectrometry. Although there are numerous commercial PCR instruments that are designed for bench-top use in a laboratory, the challenges of building a battery-powered instrument that could perform such assays in the field.
© (2003) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Raymond P. Mariella, "LLNL Center for Microtechnology: capabilities, customers, case study -- HANAA (Handheld Nucleic Acid Analyzer)", Proc. SPIE 5001, Optical Engineering at the Lawrence Livermore National Laboratory, (18 June 2003); doi: 10.1117/12.500360; https://doi.org/10.1117/12.500360
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