Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation

Suzanne T. Witt; Christian H. Riedel M.D.; Mario Goessl M.D.; Michael S. Chmelik; Erik Leo Ritman M.D.

doi:10.1117/12.480232

5 June 2003 Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation

Suzanne T. Witt, Christian H. Riedel M.D., Mario Goessl M.D., Michael S. Chmelik, Erik Leo Ritman M.D.

Proceedings Volume 5030, Medical Imaging 2003: Physics of Medical Imaging; (2003) https://doi.org/10.1117/12.480232
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

Micro-CT angiography of small laboratory mammal organs visualizes vascular branches on a large range of scales, ranging from root-level branches (~ 1 mm) to endarteriolar vessels (10-40 μm). Multiscale vascular tree segmentation is facilitated by the ability to set a single grayscale threshold value for vessels of all generation levels. Due to the non-ideal modulation transfer function (MTF) of the imaging system, object contrast varies significantly with scale, and the definition of a grayscale threshold for vessel segmentation becomes a problem. We found that performing a point spread function (PSF) deconvolution on the micro-CT projection images significantly reduces the thresholding problem in terms of restoring the smallest vessels' grayscale and delineation. The increased noise from performing a PSF deconvolution will not have a significant effect on the overall signal-to-noise ratio of the images. The PSF deconvolution was successful only when it accommodated the spatial variation of the PSF.

Citation Download Citation

Suzanne T. Witt, Christian H. Riedel M.D., Mario Goessl M.D., Michael S. Chmelik, and Erik Leo Ritman M.D. "Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation", Proc. SPIE 5030, Medical Imaging 2003: Physics of Medical Imaging, (5 June 2003); https://doi.org/10.1117/12.480232

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