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5 June 2003 Quantitative proton radiography of an animal patient
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Images (with a spatial resolution of 1 mm x 1mm) were produced both, with range and range dilution information of the protons passing through a dog. The radiographies were taken prior to a proton radiotherapy treatment of a nasal tumor, while the dog patient was under anesthetics. The first image was created by calculating the mean range of the protons detected in each pixel. This image was compared to calculations of the treatment planning system based on a CT-scan of the dog. Errors in the calculated range could be detected. The second image was produced by calculating the width of the range spectrum in each pixel. This value is a measure of the dilution of the range due to tissue inhomogeneities. The dilution image can be used to indicate critical situations during proton therapy, to determine the safety margin around the tumor volume, or to optimise treatment. In a preliminary analysis of the radiography data we found range uncertainty and range dilution effects in the order of up to 10 mm.
© (2003) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Uwe Schneider, Matthias Dellert, Eros Pedroni, Peter Pemler, Juergen Besserer, Martin Moosburger, Prisca Theiler, and Barbara Kaser-Hotz "Quantitative proton radiography of an animal patient", Proc. SPIE 5030, Medical Imaging 2003: Physics of Medical Imaging, (5 June 2003);

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