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15 May 2003 Three-dimensional active contour model for characterization of solid breast masses on three-dimensional ultrasound images
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Abstract
The accuracy of discrimination between malignant and benign solid breast masses on ultrasound images may be improved by using computer-aided diagnosis and 3-D information. The purpose of this study was to develop automated 3-D segmentation and classification methods for 3-D ultrasound images, and to compare the classification accuracy based on 2-D and 3-D segmentation techniques. The 3-D volumes were recorded by translating the transducer across the lesion in the z-direction while conventional 2-D images were acquired in the x-y plane. 2-D and 3-D segmentation methods based on active contour models were developed to delineate the mass boundaries. Features were automatically extracted based on the segmented mass shapes, and were merged into a malignancy score using a linear classifier. 3-D volumes containing biopsy-proven solid breast masses were collected from 102 patients (44 benign and 58 malignant). A leave-one-out method was used for feature selection and classifier design. The area Az under the test receiver operating characteristic curves for the classifiers using the 3-D and 2-D active contour boundaries were 0.88 and 0.84, respectively. More than 45% of the benign masses could be correctly identified using the 3-D features without missing a malignancy. Our results indicate that an accurate computer classifier can be designed for differentiation of malignant and benign solid breast masses on 3-D sonograms.
© (2003) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Berkman Sahiner, Aditya Ramachandran, Heang-Ping Chan, Marilyn A. Roubidoux, Lubomir M. Hadjiiski, Mark A. Helvie M.D., Nicholas Petrick, and Chuan Zhou "Three-dimensional active contour model for characterization of solid breast masses on three-dimensional ultrasound images", Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003); https://doi.org/10.1117/12.483548
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