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15 May 2003 Vascular MR segmentation: wall and plaque
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Cardiovascular events frequently result from local rupture of vulnerable atherosclerotic plaque. Non-invasive assessment of plaque vulnerability is needed to allow institution of preventive measures before heart attack or stroke occur. A computerized method for segmentation of arterial wall layers and plaque from high-resolution volumetric MR images is reported. The method uses dynamic programming to detect optimal borders in each MRI frame. The accuracy of the results was tested in 62 T1-weighted MR images from 6 vessel specimens in comparison to borders manually determined by an expert observer. The mean signed border positioning errors for the lumen, internal elastic lamina, and external elastic lamina borders were -0.12±0.14 mm, 0.04±0.12mm, and -0.15±0.13 mm, respectively. The presented wall layer segmentation approach is one of the first steps towards non-invasive assessment of plaque vulnerability in atherosclerotic subjects.
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Fuxing Yang, Gerhard Holzapfel, Christian Schulze-Bauer, Rudolf Stollberger, Daniel Thedens, Lizann Bolinger, Alan Stolpen, and Milan Sonka "Vascular MR segmentation: wall and plaque", Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003);

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