Ultrasound elastomicroscopy for articular cartilage: from static to transient and 1D to 2D

Yongping Zheng; Sharon Lori Bridal; Jun Shi; Amena Saied; Minghua Lu; Britta Jaffre; Arthur F. T. Mak; Pascal Laugier; Ling Qin

doi:10.1117/12.479896

23 May 2003 Ultrasound elastomicroscopy for articular cartilage: from static to transient and 1D to 2D

Yongping Zheng, Sharon Lori Bridal, Jun Shi, Amena Saied, Minghua Lu, Britta Jaffre, Arthur F. T. Mak, Pascal Laugier, Ling Qin

Author Affiliations +

Proceedings Volume 5035, Medical Imaging 2003: Ultrasonic Imaging and Signal Processing; (2003) https://doi.org/10.1117/12.479896
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

Articular cartilage (AC) is a biological weight-bearing tissue covering the ends of articulating bones within synovial joints. Its function very much depends on the unique multi-layered structure and the depth-dependent material properties, which have not been well invetigated nondestructively. In this study, transient depth-dependent material properties of bovine patella cartilage were measured using ultrasound elastomicroscopy methods. A 50 MHz focused ultrasound transducer was used to collect A-mode ultrasound echoes from the articular cartilage during the compression and subsequent force-relaxation. The transient displacements of the cartilage tissues at different depths were calculated from the ultrasound echoes using a cross-correlation technique. It was observed that the strains in the superficial zone were much larger than those in the middle and deep zones as the equilibrium state was approached. The tissues inside the AC layer continued to move during the force-relaxation phase after the compression was completed. This process has been predicted by a biphasic theory. In this study, it has been verified experimentally. It was also observed that the tissue deformations at different depths of AC were much more evenly distributed before force-relaxation. AC specimens were also investigated using a 2D ultrasound elastomicroscopy system that included a 3D translating system for moving the ultrasound transducer over the specimens. B-mode RF ultrasound signals were collected from the specimens under different loading levels applied with a specially designed compressor. Preliminary results demonstrated that the scanning was repeatable with high correlation of radio frequency signals obtained from the same site during different scans when compression level was unchanged (R² > 0.97). Strains of the AC specimens were mapped using data collected with this ultrasound elastomicroscope. This system can also be potentially used for the assessment of other biological tissues, bioengineered tissues or biomaterials with fine structures.

Citation Download Citation

Yongping Zheng, Sharon Lori Bridal, Jun Shi, Amena Saied, Minghua Lu, Britta Jaffre, Arthur F. T. Mak, Pascal Laugier, and Ling Qin "Ultrasound elastomicroscopy for articular cartilage: from static to transient and 1D to 2D", Proc. SPIE 5035, Medical Imaging 2003: Ultrasonic Imaging and Signal Processing, (23 May 2003); https://doi.org/10.1117/12.479896

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available