28 July 2003 Experimental analysis on the properties of polypyrrole as drug delivery system materials
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Abstract
A quantitative analysis of drug release characteristics of polypyrrole (PPy) was performed for its application to a drug delivery system (DDS). The incorporation of various chemical substances into the PPy and controlling its release with the externally applied voltage to the PPy are possible. A qualitative drug release characteristics of the PPy was first examined using an indicator, phenolred and then the quantitative analysis was performed using salicylate as a dopant. A drug release characteristics with time was thoroughly investigated while varying the electrode area, polymerization time, the applied voltage for drug release. Based on these quantitative results, a preliminary experiment was carried out to check the feasibility of the PPy applicable to the neuronal system. Experimental results show that a neurotransmitter was released from the PPy with the externally applied voltage and hence the PPy can be applicable in a neuronal system.
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Seung-Ki Lee, Seung-Ki Lee, Sang-Jo Lee, Sang-Jo Lee, Sung-Hwan Cho, Sung-Hwan Cho, Jungho Pak, Jungho Pak, Byungkyu Kim, Byungkyu Kim, } "Experimental analysis on the properties of polypyrrole as drug delivery system materials", Proc. SPIE 5051, Smart Structures and Materials 2003: Electroactive Polymer Actuators and Devices (EAPAD), (28 July 2003); doi: 10.1117/12.484386; https://doi.org/10.1117/12.484386
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