22 September 2003 Ocular scanning instrumentation: confirmation of biomarkers for anticholinesterase and cyanide exposure
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The sensitivity of the eye’s reaction to a wide variety of chemicals/toxins and its role as a gauge for internal homeostasis (e.g., cardiovascular and neurophysiological imbalances) has been extensively researched via many scientific disciplines. New techniques and equipment are both harnessing and utilizing this information to define a modern approach to the field of non-invasive early detection of a vast range of physical abnormalities, injuries, and illnesses. Early detection provides an invaluable tool in the subsequent success of treating such conditions. The application of these techniques to the detection of exposure to chemical threat agents such as organophosphate nerve agents and cyanide provides an important advancement in the ability to limit the deleterious effects of these agents. The Ocular Scanning Instrumentation (OSI) technology involves the use of an automated device for the continuous or programmed monitoring of optically apparent characteristic(s) and attributes of the eye that may serve as an early-warning system for possible complications based upon generalized information obtained from ocular biomarkers. Described herein is the analysis of primary ocular biomarkers for organophosphate (miosis) and cyanide (venous blood coloration) exposure.
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Lance R. Molnar, Kurt A. Henry, James Vernon Odom, Christopher J. Kolanko, "Ocular scanning instrumentation: confirmation of biomarkers for anticholinesterase and cyanide exposure", Proc. SPIE 5071, Sensors, and Command, Control, Communications, and Intelligence (C3I) Technologies for Homeland Defense and Law Enforcement II, (22 September 2003); doi: 10.1117/12.502489; https://doi.org/10.1117/12.502489

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