Stochastic dynamics of enzymes: molecular scissors

Olga A. Chichigina; Werner O. Ebeling; V. G. Makarov; Alexei V. Netrebko; Yury M. Romanovsky; Lutz Schimansky-Geier

doi:10.1117/12.497382

30 April 2003 Stochastic dynamics of enzymes: molecular scissors

Olga A. Chichigina, Werner O. Ebeling, V. G. Makarov, Alexei V. Netrebko, Yury M. Romanovsky, Lutz Schimansky-Geier

Proceedings Volume 5110, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems; (2003) https://doi.org/10.1117/12.497382
Event: SPIE's First International Symposium on Fluctuations and Noise, 2003, Santa Fe, New Mexico, United States

Abstract

The problems studied here are relevant for an understanding of the functioning of hydrolytic enzyme molecules. These enzymes work like molecular machines breaking off the valence peptid bonds of substrates. In particular the role of Fermi resonance which is evident from a spectral lines of valence oscillations is studied. The influence of this resonance on valence splitting is discussed. It is shown that the breaking of these bonds has a higher probability, if the stochastic oscillations of atoms in catalytic groups at the active site have a large quality coefficient. We show that the corresponding low damping is essential for the Fermi resonance modes of these oscillations.

Citation Download Citation

Olga A. Chichigina, Werner O. Ebeling, V. G. Makarov, Alexei V. Netrebko, Yury M. Romanovsky, and Lutz Schimansky-Geier "Stochastic dynamics of enzymes: molecular scissors", Proc. SPIE 5110, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems, (30 April 2003); https://doi.org/10.1117/12.497382

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