29 April 2003 Physics of drug delivery: dielectric spectroscopy to probe mucoadhesion
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Abstract
This work presents how dielectric spectroscopy can be used as a tool to obtain insight about properties on the nano-scale of interfaces of pharmaceutical interest. An outline for studying the adhesion in terms of a compatibility factor between pharmaceutical gels and biological tissue is put forward. The proposed compatibility factor is calculated from the high frequency response (kHz region) of the gel and porcine nasal mucosa separately, and from that of the combined system. It gives an assessment of the possibilities of intimate surface contact, which is generally considered to be the first step in the mucoadhesion process. The results from dielectric spectroscopy were compared to measurements using a tensile strength method and it was found that the gels with the highest compatibility factors were the same as those pointed out as having the highest mucoadhesion using the tensile strength method.
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Maria Stromme, "Physics of drug delivery: dielectric spectroscopy to probe mucoadhesion", Proc. SPIE 5118, Nanotechnology, (29 April 2003); doi: 10.1117/12.497685; https://doi.org/10.1117/12.497685
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