2 October 2003 Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique
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Abstract
We describe two novel techniques for contrast enhancement in optical coherence tomography (OCT) which enables molecular specific imaging. The first, a pump-probe technique, is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample arm light acting as probe light. Preliminary results exhibiting contrast enhancement in cross-sectional OCT images using methylene blue dye are presented. The second method is an optical switch suppression technique based on the use of a transmembrane protein called bacteriorhodopsin. Initial experiments indicate that biochemical optical switches, such as bacteriorhodopsin, are excellent contrast agent candidates for molecular contrast OCT.
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Changhuei Yang, Changhuei Yang, K. Divakar Rao, K. Divakar Rao, Michael Choma, Michael Choma, Siavash Yazdanfar, Siavash Yazdanfar, Andrew M. Rollins, Andrew M. Rollins, Joseph A. Izatt, Joseph A. Izatt, } "Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique", Proc. SPIE 5140, Optical Coherence Tomography and Coherence Techniques, (2 October 2003); doi: 10.1117/12.501007; https://doi.org/10.1117/12.501007
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