Application of laser-induced autofluorescence spectra detection in human colorectal cancer screening

Sheng Fu; Teck-Chee Chia; Leong Chuan Kwek; Cheong Hoong Diong; Choong Leong Tang; Francis Seow Choen; S. M. Krishnan

doi:10.1117/12.500455

8 October 2003 Application of laser-induced autofluorescence spectra detection in human colorectal cancer screening

Sheng Fu, Teck-Chee Chia, Leong Chuan Kwek, Cheong Hoong Diong, Choong Leong Tang, Francis Seow Choen, S. M. Krishnan

Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.500455
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

We investigated 48 normal patients and 25 diseased patients using our laser-induced autofluorescence spectra detection system during their regular colonoscopy. The colon and rectum mucosa autofluorescence were excited by 405 nm continue wavelength laser. We observed that cancer or diseased colorectal mucosa, their autofluorescence spectra are significantly different from normal area. The autofluorescence spectra intensity at about 500 nm was been used for our intensity ratio characteristics intensity for our diagnostic algorithm. The intensity ratios of R_I-680/I-500 and R_I-630/I-500 were performed to identify the detection area. From experimental result we concluded that both intensity ratios of R_I-680/I-500 and R_I-630/I-500 as guidelines can detect cancerous and polyps disease completely. Our investigation provided some useful insight for laser induced autofluorescence spectra as a diagnosis technique for clinical application.

Citation Download Citation

Sheng Fu, Teck-Chee Chia, Leong Chuan Kwek, Cheong Hoong Diong, Choong Leong Tang, Francis Seow Choen, and S. M. Krishnan "Application of laser-induced autofluorescence spectra detection in human colorectal cancer screening", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.500455

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